evaluation of oxidative dna cleavage of copper (ii) complexes as chemotherapeutic agents
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چکیده
منابع مشابه
DNA binding and oxidative cleavage activity of ternary (L-proline)copper(II) complexes of heterocyclic bases
Ternary copper(II) complexes [Cu(L-pro)(B)(H2O)](NO3) (1, 2) where L-pro = L-proline, B is a N,N-donor heterocyclic base, viz. 2,2 0bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), are synthesized, characterized, and their DNA binding and cleavage activity studied. The bpy complex (1) is structurally characterized by single-crystal X-ray crystallography. The complexes show the presence of a ...
متن کاملPhotoenhanced oxidative DNA cleavage with non-heme iron(II) complexes.
The DNA cleavage activity of iron(II) complexes of a series of monotopic pentadentate N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine (N4Py)-derived ligands (1-5) was investigated under laser irradiation at 473, 400.8, and 355 nm in the absence of a reducing agent and compared to that under ambient lighting. A significant increase in activity was observed under laser irradiation, which is ...
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This fourth, thoroughly revised, edition of Calmette's well-known manual aims to bring together the maximum of information which will be of value to the bacteriologist in his daily work. It is based largely on the techniques utilized at the Pasteur Institute in Paris. The topics included differ from those found in similar manuals in this country which are usually texts of laboratory diagnosis a...
متن کاملRed-light photosensitized cleavage of DNA by (l-lysine)(phenanthroline base)copper(II) complexes.
Ternary copper(II) complexes [Cu(l-lys)B(ClO4)](ClO4)(1-4), where B is a heterocyclic base, viz. 2,2'-bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 3) and dipyrido[3,2-a:2',3'-c]phenazene (dppz, 4), are prepared and their DNA binding and photo-induced DNA cleavage activity studied (l-lys =l-lysine). Complex 2, structurally characterized by X-ray cr...
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New symmetrical acyclic binuclear copper (II) complexes [CuL](ClO4)2 1 and 2 were synthesized by template method, from bicompartmental ligand 2,6-bis((E)-(2-(2aminoethylamino)ethylimino)methyl)-4-methylphenol (L) and 2-((7E)-(2-((Z)-2-((naphthalen-1-yl) methyleneamino)ethylamino)ethylimino)methyl)-6-((9E)-(2-((Z)-2-((naphthalen-1-yl)methyleneamino) ethylamino)ethylimino) methyl)-4-methylphenol ...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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